发明名称 |
Targeting VEGF-B regulation of fatty acid transporters to modulate human diseases |
摘要 |
<p>The present invention provides materials and methods for modulating FATP expression and/or activity in vivo. In particular, the present invention concerns an oligonucleotide which inhibits VEGF-B expression for use in the treatment or prophylaxis of type II diabetes or metabolic syndrome wherein the oligonucleotide is selected from (a) an antisense oligonucleotide that inhibits VEGF-B transcription or translation or an expression vector which expresses such an oligonucleotide; or (b) a dsRNA that affects RNA interference or expresses such a dsRNA.</p> |
申请公布号 |
EP2548579(B1) |
申请公布日期 |
2015.09.02 |
申请号 |
EP20120178908 |
申请日期 |
2007.05.17 |
申请人 |
THE LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
ERIKSSON, ULF |
分类号 |
A61K39/395;C07K16/00;C07K16/22;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|