Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same

摘要

A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached to denatured fibrinogen or a therapeutic portion of the fibrinogen, the composition being formulated for releasing the therapeutic portion of the fibrinogen in a pharmacokinetically regulated manner, thereby treating the disorder characterized by tissue damage or malformation.

主权项

1. A scaffold comprising a plurality of denatured fibrinogen molecules and a plurality of crosslinked synthetic polymers, each of said denatured fibrinogen molecules being covalently attached to at least two of said crosslinked synthetic polymers, wherein said synthetic polymers are crosslinked between said polymers.