| 发明名称 | Methods of manufacturing bioactive gels from extracellular matrix material | ||
| 摘要 | The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels. | ||
| 申请公布号 | US9119831(B2) | 申请公布日期 | 2015.09.01 |
| 申请号 | US201414332465 | 申请日期 | 2014.07.16 |
| 申请人 | ACell, Inc. | 发明人 | Kentner Kimberly A.;Stuart Katherine A.;Janis Abram D. |
| 分类号 | C12N5/00;C12N5/02;A61K35/37;A61K35/38;A61K35/407;A61K35/22;A61L27/36;A61L27/52;A61L27/54;A61K9/00;A61K35/12;A61K38/18 | 主分类号 | C12N5/00 |
| 代理机构 | Burns & Levinson LLP | 代理人 | Burns & Levinson LLP |
| 主权项 | 1. A bioactive wound healing material, comprising: a gelled extracellular matrix material in a basic solution wherein the extracellular matrix material is derived from the extracellular matrix of a mammal and comprises a concentration of ECM to a base (w/v) in the range of 0.1% to about 20%, wherein said wound healing material is gelled at room temperature. | ||
| 地址 | Columbia MD US | ||