| 主权项 |
1. A compound according to Formula I; or a pharmaceutically acceptable salt thereof: wherein: R1 is —NHCOR″, where R″ is:
an aryl substituted with one or more hydroxy, nitro, amino, alkyl, alkenyl, aryl, alkoxy or halo groups;a heterocyclic group, wherein the heterocyclic group is aromatic, wherein the heterocyclic group is optionally substituted with one or more hydroxy, nitro, amino, alkyl, alkenyl, aryl, alkoxy or halo groups; or wherein R24 and R25 are each independently H, C1-C4 alkyl, hydroxy or alkoxy; and R33 is H, C1-C4 alkyl, C1-C4 alkylamino, —(CO)—C1-C4 alkyl, or piperidinyl, each optionally substituted with C1-C4 alkyl; and R31 is H, halo, C1-C4 alkyl, hydroxy or alkoxy; and R32 is H or C1-C4 alkyl; X9 is:
—O-alkyl, substituted with one or more amino, amido, alkyl, alkoxy, halo, pyrrolidinyl, or hydroxyl groups;—O—alkylamino, —O—cycloalkyl, —O—(CO)—alkyl, —O—(CO)—cycloalkyl, —O—(CH2)n—pyridinyl, —O—(CH2)n-piperidinyl, —O—(CH2)n—pyrrolino, or —O—(CH2)n—pyrrolidinyl, each optionally substituted with one or more amino, amido alkyl, halo, alkoxy, or hydroxyl groups; and where n is 0, 1, 2 or 3;—O—mono-hydroxylated furanose, —O—dihydroxylated furanose, —O—mono-hydroxylated pyranose, —O—dihydroxylated pyranose, —O—trihydroxylated pyranose, —O—mono-hydroxylatedoxepinose, —O—dihydroxylated oxepinose, —O-azasugar, —O—acyl; orester, amino, amido, carbamate, phosphate ester, tosylate or mesylate; X is H, nitrile, halo, amino, amido, C1-C4 alkyl or alkoxy; and Y is H, amido, ester, amino, C1-C4 alkyl or alkoxy. |
