发明名称 Low-density magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging
摘要 This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles that contain either samarium-yttrium, samarium, or lutetium as medical isotopes for radiotherapy and/or radioimaging.
申请公布号 US9119887(B2) 申请公布日期 2015.09.01
申请号 US201012883813 申请日期 2010.09.16
申请人 MO-SCI CORPORATION 发明人 Day Delbert E.;He Yiyong
分类号 A61K51/12 主分类号 A61K51/12
代理机构 代理人
主权项 1. A radioactive low density microparticle for radioimaging or radiation therapy of a mammal comprising a biologically compatible magnesium-alumina-silicate glass microparticle having a density of about 3.0 g/cc or less said microparticle containing at least one beta or gamma radiation emitting isotope distributed substantially throughout the magnesium-alumina-silicate glass which emits a therapeutic intensity and amount of beta or gamma radiation, and a balance of elements selected from the group consisting of elements that do not become radioactive upon neutron irradiation and elements that have a half-life that is sufficiently short so that the elements do not emit a significant amount of beta or gamma radiation at the time of administration, the microparticle having a chemical durability such that subsequent to administration of the microparticle to the mammal, the microparticle will not release a significant amount of the radiation emitting radioisotope into the mammal's system; wherein the glass microparticle comprises 8-14 wt % MgO, 32-35 wt % Al2O3, and 47-52 wt % SiO2.
地址 Rolla MO US