主权项 |
1. A method of carboxylation, the method comprising:
contacting a complex of the form Z-M-OR, wherein the group Z is a nitrogen containing heterocyclic carbine, where M is copper, silver or gold, and —OR is selected from the group consisting of OH, alkoxy and aryloxy;wherein the nitrogen containing heterocyclic carbene ligand is of the form: wherein each of the groups R, R1 R2, R3 and R4 are the same or different, and the dashed line in the ring represents optional unsaturation with R1 and R2 absent; wherein each R and R1, R2, R3 and R4 are, independently for each occurrence, selected from: H, a primary or secondary alkyl group; unsaturated alkyl, alkyl-substituted, or unsubstituted phenyl; alkyl-substituted or unsubstituted naphthyl; alky-substituted or unsubstituted anthracenyl; or alkyl-substituted or unsubstituted heterocyclic aromatic rings; or wherein the nitrogen containing heterocyclic carbene ligand is from one of the formulas I, II, III, or IV: wherein each group R5, R6 and R7, is independently for each occurrence selected from: H; a primary or secondary alkyl group; alkyl-substituted or unsubstituted phenyl; alkyl-substituted or unsubstituted naphthyl; or alkyl-substituted or unsubstituted anthracenyl; wherein R8, R9, R10 and R11 are each independently for each occurrence H; a primary or secondary alkyl group; alkyl-substituted or unsubstituted aryl; or in formulas (II) and (IV) together with the carbons carrying them form a fused 4-8 membered carbocylic ring or a fused aromatic ring; and wherein R12 is alkyl or a cycloalkyl; with a reactant comprising an alkyl-substituted, halo-substituted, or unsubstituted aromatic compound; an alkyl-substituted, halo-substituted, or unsubstituted heteroaromatic compound; or an alkyl-substituted, halo-substituted, or unsubstituted heterocyclic compound; the reactant comprising a C—H or a N—H bond capable of carboxylation; and a source of CO2. |