| 发明名称 | Fluorocarbon-linked peptide formulation | ||
| 摘要 | The invention provides an aqueous acidic formulation suitable for use as in the preparation of a pharmaceutically acceptable fluorocarbon-linked peptide formulation, which aqueous formulation comprises a first fluorocarbon-linked peptide, wherein: the peptide linked to the fluorocarbon is at least 20 amino acid residues long, comprises at least 50% hydrophobic amino acid residues and has an isoelectric point greater than or equal to 7; and the fluorocarbon-linked peptide is present in micelles. | ||
| 申请公布号 | US9119811(B2) | 申请公布日期 | 2015.09.01 |
| 申请号 | US201113977265 | 申请日期 | 2011.12.30 |
| 申请人 | Vaxin UK Limited | 发明人 | Brown Carlton Bradley;Georges Bertrand Victor Gilbert;Thaburet Jean Francois |
| 分类号 | A61K9/00;A61K39/12;A61K38/00;C07K5/00;C07K7/00;C07K16/00;C07K17/00;C07K1/00;A61K39/145;A61K39/00;A61K47/48;A61K39/385 | 主分类号 | A61K9/00 |
| 代理机构 | Goodwin Procter LLP | 代理人 | Goodwin Procter LLP |
| 主权项 | 1. An aqueous acidic formulation for use in the preparation of a pharmaceutically acceptable fluorocarbon-linked peptide formulation, the aqueous acidic formulation comprising a first fluorocarbon-linked peptide, wherein: the peptide linked to the fluorocarbon is 20 to 50 amino acid residues long, comprises at least 50% hydrophobic amino acid residues and has an isoelectric point greater than or equal to 7, but does not comprise a contiguous sequence of 20 amino acid residues comprising more than 80% hydrophobic amino acid residues; and (ii) the fluorocarbon-linked peptide is present in micelles. | ||
| 地址 | London GB | ||