| 发明名称 | Cancer vaccine composition | ||
| 摘要 | A cancer vaccine composition for human leukocyte antigen (HLA)-A*0206-positive persons, comprising a protein product of the tumor suppressor gene WT1 or a partial peptide thereof. | ||
| 申请公布号 | US9119801(B2) | 申请公布日期 | 2015.09.01 |
| 申请号 | US201313920757 | 申请日期 | 2013.06.18 |
| 申请人 | INTERNATIONAL INSTITUTE OF CANCER IMMUNOLOGY, INC. | 发明人 | Sugiyama Haruo |
| 分类号 | A61K36/00;A61K39/00;C07K7/06;C07K14/47;G01N33/569;G01N33/574 | 主分类号 | A61K36/00 |
| 代理机构 | Oblon, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. A method of cancer treatment, comprising administering to an HLA-A*0201-positive person a composition comprising the following peptide: a modified peptide of the WT1187 peptide: Ser Leu Gly Glu Gln Gln Tyr Ser Val (SEQ ID NO: 2) or the WT1126 peptide: Arg Met Phe Pro Asn Ala Pro Tyr Leu (SEQ ID NO: 3), wherein the modified peptide is a peptide comprising the amino acid residues at position 4 to 8 from the N terminus of the WT1187 or WT1126 peptide and is immunogenic in HLA-A*0201-positive persons. | ||
| 地址 | Suita-shi JP | ||