Surface treatments for promoting selective tissue attachment to medical impants

摘要

Embodiments include a method for promoting selective tissue attachment to medical implants. By treating implant surfaces where tissue attachment is desired with tissue attachment promoting treatments, and treating implant surfaces where tissue attachment is not desired with tissue attachment inhibiting treatments, selective tissue attachment to medical implants may be achieved. Also, embodiments include an implant with at least one tissue contacting surface and at least one secondary surface where tissue attachment is not desired, and appropriate tissue attachment promoting or inhibiting treatments on the surfaces.

主权项

1. A method for promoting selective endogenous tissue attachment to an osteoimplant, comprising:
providing an osteoimplant having at least one endogenous tissue contacting surface where endogenous tissue attachment is desired, and at least one endogeneous tissue contacting surface where endogenous tissue attachment is not desired; treating surfaces of the osteoimplant where endogenous tissue attachment is desired with a tissue attachment promoting treatment; and treating surfaces of the osteoimplant where endogenous tissue attachment is not desired with an endogenous tissue attachment inhibiting treatmentwherein the tissue attachment promoting treatment comprises a tissue attachment formulation comprising a series of growth factors in a time dependent release formulation, the formulation comprising at least two agents selected from the group consisting of vascular growth promoting agents or factors, collagen/cartilage stimulation agents, osteoconductive agents and/or osteoinductive agents, and mixtures thereof, the at least two agents being combined with a sustained release polymer or biodegradable polymer having variable release rates such that at least one agent is released prior to an at least second agent.