| 发明名称 |
Carious tooth vaccine and preparation method |
| 摘要 |
The present invention provides a vaccine composition for dental caries caused by S. mutans infection, where the vaccine composition comprises an antigen derived from a surface protein PAc of S. mutans and an adjuvant derived from flagellin. The present invention further provides methods for preparing the vaccine composition. The present invention also provides methods for preventing or curing dental caries caused by S. mutans by administrating to a subject the vaccine composition. |
| 申请公布号 |
US9119803(B2) |
申请公布日期 |
2015.09.01 |
| 申请号 |
US201114234145 |
申请日期 |
2011.12.29 |
| 申请人 |
Wuhan Institute of Virology, Chinese Academy of Sciences |
发明人 |
Yan Huimin;Shi Wei;Sun Ying;Yang Jingyi |
| 分类号 |
A61K39/09;A61K39/02;A61K39/00 |
主分类号 |
A61K39/09 |
| 代理机构 |
|
代理人 |
Liu George Dacai |
| 主权项 |
1. A vaccine composition for dental caries caused by S. mutans infection, comprising:
a PAc polypeptide encoded by SEQ ID NO 1 or a variant of the PAc polypeptide represented by SEQ ID NO 2; a flagellin polypeptide encoded by SEQ ID NO 3 or a variant of the flagellin represented by SEQ ID NO 4, wherein the flagellin polypeptide or flagellin variant contains a deletion in hypervariable domain of flagellin polypeptide; and a pharmaceutically acceptable carrier. |
| 地址 |
Wuhan CN |
