System for performing remote ischemic preconditioning

摘要

A system for remote ischemic preconditioning that includes a cuff, and actuator, and a controller that operates the actuator according to a treatment protocol. The treatment protocol includes a plurality of treatment cycles that each comprise cuff actuation, an ischemic duration, cuff release, and a reperfusion duration.

主权项

1. A method for reducing ischemic injury to tissue in a subject during subsequent ischemic episodes by performing remote ischemic preconditioning on the subject at a location remote from the tissue using a cuff system configured to be positioned about a limb of the subject, wherein the remote ischemic preconditioning is performed as a treatment protocol that includes a plurality of sequentially actuated treatment cycles, wherein the cuff system comprises:
a single cuff having a single bladder configured to retract about the limb of a subject; an actuator connected to the cuff and that, when actuated, causes the cuff to contract about the limb of the subject to reduce blood flow there through; and a controller that controls the actuator to operate according to the treatment protocol that includes the plurality of sequentially actuated treatment cycles, each treatment cycle comprising: cuff actuation during which the actuator contracts the cuff about the limb of the subject to a pressure to occlude blood flow through the limb; an ischemic duration of more than one minute, during which the actuator maintains the cuff contracted about the limb at a set point to occlude blood flow through the limb; cuff release, during which the actuator releases the cuff to allow blood flow through the limb; and a reperfusion duration of more than one minute, during which the cuff is maintained about the limb in an at least partially relaxed state to allow blood flow through the limb.