Detection and treatment of pancreatic, ovarian and other cancers

摘要

The application provides methods of diagnosis, prognosis, prophylaxis and treatment of ovarian, pancreatic and other cancers using antibodies that specifically bind to denatured CD70.

主权项

1. A monoclonal antibody that specifically binds to denatured human CD70 on a sample of formalin fixed, paraffin-embedded cells or tissues that express human CD70, wherein the monoclonal antibody comprises three heavy chain complementarity determining regions (CDRs): heavy chain CDR1, heavy chain CDR2, and heavy chain CDR3, wherein the heavy chain CDRs are identical to the heavy chain CDRs of the antibody SG-21.1C1; and three light chain CDRs: light chain CDR1, light chain CDR2, and light chain CDR3, wherein the light chain CDRs are identical to the light chain CDRs of the antibody SG-21.1C, and wherein the antibody SG-21.1C is produced by the hybridoma deposited with the ATCC and assigned Accession No. PTA-8733.