主权项 |
1. A method of treating hypotyalism in a human in need thereof, comprising:
administering sublingually to said human in need thereof a therapeutically effective amount of a pharmaceutical composition comprising magnesium stearate, pilocarpine and a bioadhesive polymer combined in the form of a tablet,
wherein the pilocarpine is the form of a salt, chlorohydrate or nitrate, andthe bioadhesive polymer is:
a cellulose derivative selected from the group consisting of sodium carboxy-methyl cellulose, hydroxy-ethyl cellulose, hydroxy-propyl cellulose, hydroxy-propyl methyl cellulose, hydroxy-propyl methyl promellose, methyl cellulose, and carboxy-methyl cellulose,a gum selected from the group consisting of guar, xanthan, and arabic gum,a polymer selected from the group consisting of alginic acid, carboxy-vinyl polymer, carbomer, macrogol, gelatin, povidone, and pectin,or combinations thereof,wherein the tablet dissolves when placed sublingually in the mouth of the human; allowing the tablet to dissolve sublingually in the mouth of the human, wherein the composition locally adheres to and thoroughly combines with mucous tissues in a buccopharyngeal cavity of the human; allowing the pilocarpine to dissolve and bind to muscarine receptors present in cells of the human's salivary glands, endobuccal submucous glands and submaxillary glands, the bound pilocarpine then being absorbed by the cells of the human through the receptors and stimulating said glands to produce saliva, without said pilocarpine having to pass through the stomach or the liver of the human. |