Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline

摘要

The present invention relates to compounds defined by formula I;
wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

主权项

1. A solid pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent; and a compound represented by the following structural formula: wherein at least 50% by weight of the compound is a single crystalline form characterized by x-ray powder diffraction peaks at 2Θ angles selected from 13.7°, 17.6°, 21.3°, 21.9°, 23.3°, 25.6° and 26.5°.