| 主权项 |
1. A method of activating p53 response, said method comprising administering to a subject in need thereof a therapeutically useful amount of a compound according to formula (I): wherein, R1 is independently, in each instance, selected from the group cons sting of H; branched or unbranched mono-, di-, or tri-substituted or unsubstituted alkyi, alkenyl or alkynyl; aryl; and Z-alkyl, Z-alkenyl, Z-alkynyl or Z-aryl, wherein Z is O, NH, N, or S, Y is absent or —C(O)—, —C(S)— or —SO2, Ar is aryl Ar′ is a phenyl substituted at one or more available position by a C2-C10 branched or unbranched, substituted or unsubstituted alkyl, and R3 and R4 are either: each independently selected from the group consisting of: H; branched or unbranched mono-, di- or tri-substituted or unsubstituted alkyl; and Z-alkyl, wherein Z is O, NH, N or S, or, R3 and R4 are: bound together to form a branched or unbranched, substituted or unsubstituted, alkylene or Z-alkene, wherein Z is O, NH, N or S, or a physiologically acceptable salt, solvate or ester thereof, wherein said method is for the treatment of a cancer selected from the group consisting of Burkitt's lymphoma, chronic mvelogenous leukemia (CML), colon cancer, epithelial cancer, gastric cancer and neurobiastoma. |
