发明名称 |
PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES |
摘要 |
<p>This invention relates to the preparation of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid into biologically active molecules such as pregabalin.</p> |
申请公布号 |
SI2035368(T1) |
申请公布日期 |
2015.08.31 |
申请号 |
SI20070031676T |
申请日期 |
2007.06.06 |
申请人 |
LABORATORIO CHIMICO INTERNAZIONALE S.P.A. |
发明人 |
SALVI ANNIBALE;NARDI ANTONIO;DE ANGELIS BRUNO |
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