发明名称 5-amino-1- benzimidazole-pyrazole derivatives and pharmaceutical compositions comprising them
摘要 <p>A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a C 6-10 aryl group; R 1 and R 2 independently represent H, OH, X, CN, NO 2 a C 1-4 haloalkyl group, a C 1-6 alkyl group, or the like <R 1 and R 2 together form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group>; R 3 represents H, a C 1-5 alkyl group, a C 6-10 aryl group, a C 1-5 alkyl group, or a C 1-4 haloalkyl group; and R 4 represents H, X, a C 1-3 alkyl group, a C 1-4 haloalkyl group, OH, CN, NO 2 or the like.)</p>
申请公布号 IL217912(A) 申请公布日期 2015.08.31
申请号 IL20120217912 申请日期 2012.02.02
申请人 F. HOFFMANN-LA ROCHE AG;CHUGAI SEIYAKU KABUSHIKI KAISHA 发明人
分类号 A61K;A61P;C07D 主分类号 A61K
代理机构 代理人
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