发明名称 |
Methods for treating conditions associated with masp-2 dependent complement activation |
摘要 |
<p>Disclosed is the use of a MASP-inhibitory agent which inhibits MASP-2-dependent complement activation in the manufacture of a medicament for treating a subject suffering from paroxysmal nocturnal haemoglobinuria (PNH), 5 wherein the MASP-2 inhibitory agent comprises a monoclonal MASP-2 inhibitory antibody, or antigen-binding fragment thereof, that specifically binds to a portion of SEQ ID NO:6 and selectively inhibits MASP-2-dependent complement activation without substantially inhibiting the C1q-dependent complement pathway, wherein SEQ ID NO: 6 is disclosed within the specification.</p> |
申请公布号 |
NZ617298(A) |
申请公布日期 |
2015.08.28 |
申请号 |
NZ20120617298 |
申请日期 |
2012.04.06 |
申请人 |
UNIVERSITY OF LEICESTER;OMEROS CORPORATION |
发明人 |
DEMOPULOS GREGORY A.;DUDLER TOM;SCHWAEBLE HANS-WILHELM |
分类号 |
A61K39/395;A61P7/00;A61P13/12;C07K16/18 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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