发明名称 Modulation of apolipoprotein ciii (apociii) expression
摘要 Disclosed is a use of a compound targeting ApoCIII in the manufacture of a medicament for a) treating, preventing, delaying or ameliorating pancreatitis in an animal; b) increasing HDL levels and/or improving the ratio of TG to HDL in an animal thereby preventing, delaying or ameliorating a cardiovascular disease, disorder, condition or symptom thereof or onset of a cardiovascular disease, disorder, condition or symptom thereof in an animal; c) increasing HDL levels and/or improving the ratio of TG to HDL in an animal thereby reducing the risk of a cardiovascular disease, disorder, condition or symptom in an animal; and/or d) treating, preventing, delaying or ameliorating chylomicronemia, wherein the compound is capable of inhibiting apolipoprotein C-III.
申请公布号 NZ616779(A) 申请公布日期 2015.08.28
申请号 NZ20120616779 申请日期 2012.04.27
申请人 ISIS PHARMACEUTICALS INC. 发明人 MULLICK ADAM;CROOKE ROSANNE M.;GRAHAM MARK J.;DOBIE KENNETH W.;BELL THOMAS A.;LEE RICHARD
分类号 A61K31/7088;A61P3/06 主分类号 A61K31/7088
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