发明名称 |
INSULINOTROPIC PEPTIDE DERIVATIVE WITH MODIFIED N-TERMINAL CHARGE |
摘要 |
The present invention relates to an insulinotropic peptide derivative with a modified N-terminal charge and a pharmaceutical composition including the same. Specifically, the insulinotropic peptide derivative is characterized in that the N-terminal positive charge of the insulinotropic peptide is modified to a neutral or net negative charge at neutral pH. The insulinotropic peptide derivative according to the present invention is rapidly dissociated from the GLP-1 receptor owing to the above modification in the N-terminal charge, and exhibits enhanced insulinotropic ability and blood glucose-lowering activity compared to the native insulinotropic peptide while maintaining its stability in blood. Accordingly, the insulinotropic peptide derivative of the present invention is very useful for the treatment of type 2 diabetes. |
申请公布号 |
SG11201505197Y(A) |
申请公布日期 |
2015.08.28 |
申请号 |
SG11201505197Y |
申请日期 |
2014.01.03 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
JUNG, SUNG YOUB;HWANG, SANG YOUN;CHOI, IN YOUNG;PARK, SUNG HEE;KWON, SE CHANG |
分类号 |
C07K14/575;A61P3/10 |
主分类号 |
C07K14/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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