发明名称 |
C-MYC AS A BIOMARKER FOR TUMOR SENSITIVITY TO TREATMENT WITH RNA POLYMERASE II INHIBITION |
摘要 |
Systems and methods for determining whether a cancer patient may respond to inhibition of RNA polymerase II as a treatment for the patient are provided. Inhibition of RNA polymerase II may be by way of chemotherapy with an agent such as triptolide, an analog of triptolide, or a prodrug form of triptolide. The cancer patient may be a pancreatic cancer patient, an ovarian cancer patient, a gastric cancer patient, or an esophageal cancer patient. The patient may have any cancer in which c-Myc is over-expressed or over- amplified. |
申请公布号 |
WO2015127011(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
WO2015US16504 |
申请日期 |
2015.02.19 |
申请人 |
INSTITUTE OF CANCER RESEARCH D/B/A THE RESEARCH INSTITUTE OF FOX CHASE CANCER CENTER |
发明人 |
ASTSATUROV, IGOR;KHAZAK, VLADIMIR;SEREBRIISKI, ILYA |
分类号 |
C12Q1/68;A01N43/08;C07D321/00 |
主分类号 |
C12Q1/68 |
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