Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone

摘要

PROCESS FOR PREPARING OXYCODONE HYDROCHLORIDE HAVING LESS THAN 25 PPM 14-HYDROXYCODEINONE Abstract Oxycodone is a semi-synthetic opioid analgesic that exerts an agonist effect at specific, saturatable opioid receptors in the CNS and other tissues. 14-hydroxycodeinone is an impurity formed in the production of oxycodone from thebaine. The invention provides a purified oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and processes for its production.