发明名称 DEPROTECTION METHOD FOR TETRAZOLE COMPOUND
摘要 The present invention relates to a method of deprotecting a tetrazole compound, useful as an intermediate for angiotensin II receptor blockers, and provides a novel production method of angiotensin II receptor blockers.;Provided is a production method of a compound represented by the formula [3] or [4] or a salt thereof, including (i) reducing a compound represented by the formula [1] or [2] or a salt thereof in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting the compound with a particular amount of Brønsted acid:;;wherein each symbol is as defined in the present specification.
申请公布号 US2015239854(A1) 申请公布日期 2015.08.27
申请号 US201314429257 申请日期 2013.09.26
申请人 API CORPORATION 发明人 Seki Masahiko
分类号 C07D257/04;C07D403/10;B01J23/58;C07D405/14 主分类号 C07D257/04
代理机构 代理人
主权项 1. A method of producing a compound represented by the formula [3]: wherein R1 is an alkyl group, an aralkyl group or an aryl group, each of which is optionally substituted, or a salt thereof, or the formula [4]: wherein the symbol is as defined above, or a salt thereof, comprising (i) reducing a compound represented by the formula [1]: wherein R1 is as defined above, each R2 is an alkyl group, an alkoxy group or a nitro group, or two alkoxy groups are optionally bonded to form an alkylenedioxy group, and p is an integer of 0 to 5, or a salt thereof, or a compound represented by the formula [2]: wherein each symbol is as defined above, or a salt thereof, in the presence of a metal catalyst and an alkaline earth metal salt, or (ii) reacting a compound represented by the formula [1] or a salt thereof or a compound represented by the formula [2] or a salt thereof with 0.1 equivalents-50 equivalents of Brønsted acid relative to compound [1] or compound [2].
地址 Tokyo JP