发明名称 |
Multifunctional Oral Vaccine Based on Chromosome Recombineering |
摘要 |
A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome for the purpose of making multivalent vaccines to protect against one or more disease agents are described herein. |
申请公布号 |
US2015238591(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
US201314428870 |
申请日期 |
2013.09.16 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV |
发明人 |
Dharmasena Madushini Nirosha;Kopecko Dennis J. |
分类号 |
A61K39/112;C07K14/255;C12N1/20;C07K14/25 |
主分类号 |
A61K39/112 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Rockville MD US |