发明名称 |
CANCER TREATMENTS USING ERK1/2 AND BCL-2 FAMILY INHIBITORS |
摘要 |
The present invention provides, inter alia, methods for treating or ameliorating the effects of a cancer in a subject in need thereof. These methods include administering to the subject an effective amount of (i) an ERK1/2 inhibitor (such as BVD-523) or a pharmaceutically acceptable salt thereof and (ii) a BCL-2 family inhibitor (such as navitoclax) or a pharmaceutically acceptable salt thereof, to treat or ameliorate the effects of the cancer. Kits and pharmaceutical compositions for treating or ameliorating the effects of a cancer in a subject and methods for selecting a subject with cancer that may benefit from a combination drug therapy are also provided. |
申请公布号 |
WO2015095834(A3) |
申请公布日期 |
2015.08.27 |
申请号 |
WO2014US71736 |
申请日期 |
2014.12.19 |
申请人 |
BIOMED VALLEY DISCOVERIES, INC. |
发明人 |
SAHA, SAURABH;WELSCH, DEAN;DECRESCENZO, GARY;ROIX, JEFFREY, JAMES |
分类号 |
A61K31/5377;A61K31/166;A61K31/277;A61K31/352;A61K31/4412;A61K31/444 |
主分类号 |
A61K31/5377 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|