| 发明名称 |
IRHOM2 INHIBITION FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS |
| 摘要 |
Disclosed are methods for treating a subject with a Complement mediated (e.g., C5a mediated) disease or an immune complex mediated disease. The method comprises the step of administering to the subject an effective amount of an agent that decreases the biological activity of iRhom2 or an agent that modulates formation of a complex between iRhom2 and TACE. Also disclosed are assays for identifying such agents. |
| 申请公布号 |
US2015241429(A1) |
申请公布日期 |
2015.08.27 |
| 申请号 |
US201314427185 |
申请日期 |
2013.09.11 |
| 申请人 |
HOSPITAL FOR SPECIAL SURGERY ;UNIVERSITY HEALTH NETWORK |
发明人 |
Issuree Priya;Maretzky Thorsten;McIlwain David;Mak Tak Wah;Blobel Carl;Salmon Jane |
| 分类号 |
G01N33/573;C12Q1/68;C12Q1/37 |
主分类号 |
G01N33/573 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating a subject with a Complement mediated disease or an immune complex mediated disease, comprising the step of administering to the subject an effective amount of an agent that decreases the biological activity of iRhom2. |
| 地址 |
New York NY US |
