| 摘要 |
The present invention provides a process for preparing a compound of formula: (Formula XI and XII) (XI) (XII) wherein X, Y, Z, A, B and E are as defined herein, by reacting a compound of formula: (Formula XIII) (XIII) with a compound of formula: (Formula XIV and XV) (XIV) (XV) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates.; |
| 主权项 |
1. A process for preparing a compound of formula: wherein: X is H, halo, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), —Si(R3)3 [wherein R3 is, independently in each case, C1-C6 alkyl, Aryl or Aryl(C1-C6 alkyl)], —O(C1-C6 alkyl), —OAryl, —S(C1-C6 alkyl), —OSO2(C1-C6 alkyl), —NNSO2(C1-C6 alkyl) or —SAryl; Y is H, halo, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), —Si(R3)3 [wherein R3 is as defined above], —O(C1-C6 alkyl), —OAryl, —S(C1-C6 alkyl), —OSO2(C1-C6 alkyl), —NHSO2(C1-C6 alkyl) or —SAryl; Z is optionally substituted heteroaryl, —Si(R3)3 (wherein R3 is as defined above), —OH, a protected hydroxyl group, halo, nitro, cyano, —SH, a protected thio group, C1-C6 alkyl or C1-C6 alkoxy; A is O, S or NH; B is phenyl substituted by one or more halo atoms; and D is a halo atom; by reacting a compound of formula: wherein Z and B are as defined above, with a compound of formula: respectively, wherein X, Y, A and D are as defined above, in the presence of a transition metal catalyst, a ligand suitable for use with the catalyst and a reducing agent. |
