发明名称 |
MITOCHONDRIAL ALDEHYDE DEHYDROGENASE 2 (ALDH2) BINDING POLYCYCLIC AMIDES AND THEIR USE FOR THE TREATMENT OF CANCER |
摘要 |
The present invention provides compounds of formula I that bind to mitochondrial aldehyde dehydrogenase-2 (ALDH2), and methods of using said compounds to treat patients with i.a. cancer, Fanconi anemia and alcohol-related disorders. [Formula should be inserted here] wherein i.a. A is O or NH; RA is H, cycloalkyl or alkyl optionally substituted with a carbocycle; X1 and X2 are N or CH; R1, R2, R3 and R4 are H; and Z is an optionally substituted 5- or 6-membered aromatic ring. |
申请公布号 |
CA2940269(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
CA20152940269 |
申请日期 |
2015.02.19 |
申请人 |
AVIV THERAPEUTICS, INC. |
发明人 |
YANG, WENJIN;YU, TEH-YIE;JIANG, CHUN |
分类号 |
C07D213/82;C07C235/60;C07D213/56;C07D213/81;C07D213/89;C07D231/12;C07D233/64;C07D261/08;C07D277/30;C07D307/54;C07D333/24;C07D401/04;C07D405/12;C07D409/04;C07D413/04 |
主分类号 |
C07D213/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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