发明名称 |
Methods and compositions for delivering mRNA coded antibodies |
摘要 |
<p>The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof one or more mRNAs encoding a heavy chain and a light chain of an antibody, and wherein the antibody is expressed systemically in the subject. In some embodiments, the one or more mRNAs comprise a first mRNA encoding the heavy chain and a second mRNA encoding the light chain of the antibody.</p> |
申请公布号 |
AU2014239184(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
AU20140239184 |
申请日期 |
2014.03.14 |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
HEARTLEIN, MICHAEL;DEROSA, FRANK;GUILD, BRAYDON CHARLES;DIAS, ANUSHA |
分类号 |
C07K16/22;A61K47/48;C07K16/24;C12N15/88 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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