WATER SOLUBLE ANIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND THEIR USES

摘要

The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO<->, COS<->, SO3<->, PO3<2->, COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17<3>, 13<3>, and 3<2> of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

主权项

1. A bacteriochlorophyll derivative containing at least one negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, excluding pentacyclic bacteriochlorophyll derivatives having a free CH2CH2COOH or a CH2CH2COO− group at position 17, and tetracyclic bacteriochlorophyll derivatives devoid of a central metal atom and having a —CH2CH2COOH group at position 17, a —CH2COOH or —COOH group at position 15, a —COOH group at position 13, methyl groups at the positions 2, 7, 12, 18, and ethyl groups at the positions 3 and 8.