发明名称 |
MEDICAL IMAGE ANALYSIS FOR IDENTIFYING BIOMARKER-POSITIVE TUMOR CELLS |
摘要 |
<p>The invention relates to a medical image analysis method for identifying biomarker- positive tumor cells, the method comprising: - reading a first digital image (223) and a second digital image (222) into memory, the first and second digital image depicting the same area of a first slide; • the first slide comprising multiple tumor cells having being stained with a first stain and with a second stain; • the first stain selectively staining nuclei and the second stain selectively staining a particular biomarker, the presence and/or amount of the biomarker in a tumor cell being indicative of a tumor cell belonging to a particular cancer-subtype; - identifying a plurality of nuclei and positional information of said nuclei by analyzing the light intensities in the first digital image; - identifying cell membranes which comprise the biomarker by analyzing the light intensities in the second digital image and by analyzing the positional information of the identified nuclei; - identifying biomarker-positive tumor cells in said area, wherein a biomarker- positive tumor cell is a combination of one identified nucleus and one identified cell membrane that surrounds the identified nucleus.</p> |
申请公布号 |
WO2015124777(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
WO2015EP53757 |
申请日期 |
2015.02.23 |
申请人 |
VENTANA MEDICAL SYSTEMS, INC.;F. HOFFMANN-LA ROCHE AG |
发明人 |
CHUKKA, SRINIVAS;YUAN, QUAN |
分类号 |
G06T7/00 |
主分类号 |
G06T7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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