发明名称 |
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING CLOSTRIDIUM INFECTION |
摘要 |
Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modified Clostridium difficile toxin A and B (TcdA and TcdB) proteins are described herein, which comprise mutations that reduce toxin A and B toxicity compared to the native toxin. The proteins described are highly similar to the native toxin of Clostridium difficile, but toxicity is reduced. |
申请公布号 |
CA2939969(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
CA20152939969 |
申请日期 |
2015.02.17 |
申请人 |
THE HOSPITAL FOR SICK CHILDREN;VANDERBILT UNIVERSITY |
发明人 |
MELNYK, ROMAN;ZHANG, ZHIFEN;TAM, JOHN;LACY, DANA BORDEN;SEEBACK, STACEY A.;CHUMBLER, NICOLE M. |
分类号 |
C12N15/31;A61K39/08;A61K39/40;A61P31/04;A61P37/04;C07K7/08;C07K14/33;C07K16/12;G01N33/53;G01N33/543 |
主分类号 |
C12N15/31 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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