Novel Monoclonal Antibody Which Is Specifically Bound to TM4SF5 Protein and Use Thereof

摘要

The present invention relates to a novel monoclonal antibody which is specifically bound to a transmembrane 4 L six family member 5 (TM4SF5) protein. More particularly, the present invention relates to a monoclonal antibody which is specifically bound to a human TM4SF5 protein, to polynucleotides coding for the monoclonal antibody, to an expression vector comprising the nucleotides, to a transformant with the vector introduced thereto, to a method for preparing the monoclonal antibody, to a composition comprising the monoclonal antibody, to a method for treating liver fibrosis using the monoclonal antibody, to a method for treating cancer using the monoclonal antibody, to a method for inhibiting metastasis of cancer, to a method for diagnosing cancer using the monoclonal antibody and to a cancer diagnosis kit comprising the monoclonal antibody.

主权项

1. A monoclonal antibody which specifically binds to human transmembrane 4 L six family member 5 (TM4SF5) protein, wherein the monoclonal antibody comprises:
(a) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 2; a heavy chain CDR2 represented by SEQ ID NO: 3; and a heavy chain CDR3 represented by SEQ ID NO: 4, 12, 20, or 26; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 6 or 14; a light chain CDR2 represented by SEQ ID NO: 7 or 15; and a light chain CDR3 represented by SEQ ID NO: 8, 16, 22, or 28; or (b) a heavy chain variable region comprising a heavy chain CDR1 represented by SEQ ID NO: 32; a heavy chain CDR2 represented by SEQ ID NO: 33; and a heavy chain CDR3 represented by SEQ ID NO: 34; and a light chain variable region comprising a light chain CDR1 represented by SEQ ID NO: 36; a light chain CDR2 represented by SEQ ID NO: 15; and a light chain CDR3 represented by SEQ ID NO: 37.