| 发明名称 |
DNA Vaccines Encoding Heat Shock Proteins |
| 摘要 |
A method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences. The disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis. The administering of the immunogenic composition results in a shift of the immune response to a Th2 response, thereby treating the disease. |
| 申请公布号 |
US2015238583(A1) |
申请公布日期 |
2015.08.27 |
| 申请号 |
US201414507648 |
申请日期 |
2014.10.06 |
| 申请人 |
ALMA BIO THERAPEUTICS |
发明人 |
Cohen Irun R.;Quintana Francisco J.;Carmi Pnina;Mor Felix |
| 分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a T cell-mediated inflammatory autoimmune disease, which comprises administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding a heat shock protein 90 (HSP 90), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences, thereby treating the disease, wherein the disease is other than insulin dependent diabetes mellitus (IDDM) or rheumatoid arthritis, and wherein the administering of the immunogenic composition results in a shift of the immune response to a Th2 response. |
| 地址 |
LYON FR |
