| 发明名称 |
ISOLATING TRAFFIC-ENHANCING MUTANTS OF DRUG DELIVERY PROTEIN |
| 摘要 |
The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic agent to an organelle, comprising a polypeptide encoded by a mutant penton base gene. In another embodiment, the invention provides a method of enhancing trafficking to a cell by administering a composition comprising a penton base (PB) protein with one or more mutations that enhance cellular entry. |
| 申请公布号 |
US2015240231(A1) |
申请公布日期 |
2015.08.27 |
| 申请号 |
US201314419233 |
申请日期 |
2013.08.02 |
| 申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
Medina-Kauwe Lali K. |
| 分类号 |
C12N15/10;A61K47/48 |
主分类号 |
C12N15/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of enhancing trafficking to a cell, comprising:
providing a composition comprising a penton base (PB) protein with one or more mutations that enhance cellular entry; and administering an effective dosage of the composition to the cell. |
| 地址 |
Los Angeles CA US |
