发明名称 |
HSP104 VARIANTS AND USES THEREOF |
摘要 |
Protein misfolding underpins several fatal neurodegenerative disorders. The application is directed to recombinant Hsp104 proteins comprising missense mutations aimed at correcting these events, and methods for expressing and delivering same. |
申请公布号 |
US2015240222(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
US201514630785 |
申请日期 |
2015.02.25 |
申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Shorter James;Jackrel Meredith E. |
分类号 |
C12N9/14;A61K38/46 |
主分类号 |
C12N9/14 |
代理机构 |
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代理人 |
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主权项 |
1. A recombinant Hsp104 protein of wild type amino acid sequence of SEQ ID NO: 1, wherein said sequence comprises a missense mutation in the middle domain thereof. |
地址 |
Philadelphia PA US |