NT-proCNP AS A BIOMARKER OF VASCULAR DISORDERS AND PREGNANCY COMPLICATION

摘要

The present disclosure relates to methods for the prognosis and/or diagnosis of vascular-related disorders in a subject and in particular pregnancy-related vascular disorders. The present disclosure is based on the finding that a positive correlation exists between positive prediction of a vascular disorder event in a subject and the concentration of the circulating marker NTproCNP (also referred to as NT-CNP) in humans and animals. In addition, the present disclosure is based on the finding that there is also a positive correlation between the occurrence of a vascular-related adverse event during pregnancy and the concentration of the circulating marker NT-proCNP in the maternal circulation.

主权项

1. A method of predicting an adult subject's risk of acquiring a vascular disorder, comprising:
(i) measuring N-terminal pro-C-type natriuretic peptide (NTproCNP) in a biological sample from the subject, and (ii) comparing the measured level of NTproCNP against a reference interval from a suitable control population, wherein an increase in the circulating level of NTproCNP compared with the control population is predictive of acquiring a vascular disorder, and further wherein said measuring step comprises detecting binding between NTproCNP and a binding agent that selectively binds to NTproCNP.