发明名称 |
NOVEL, PROTECTIVE, ANTI-INFLAMMATORY RECEPTOR AND ITS USE IN PRESERVATION OF MITOCHONDRIAL FUNCTION, WOUND HEALING AND REPAIR |
摘要 |
Provided herein is a novel mitochondrial Angiotensin II type 1 and type 2 AT1R and AT2R receptor which plays a role in protection of mitochondria against oxidative damage. Evidence from animal studies indicates a role for this receptor in preservation of mitochondria and up-regulation of survival genes, anti-inflammatory action, and improvement of wound healing in the skin and soft tissues. Pharmaceutical compositions for treatment directed to preserving mitochondrial function, anti-inflammation, wound healing and decreasing the signs of aging, as well as medicaments and their use are also provided. |
申请公布号 |
US2015238465(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
US201514598105 |
申请日期 |
2015.01.15 |
申请人 |
The Johns Hopkins University |
发明人 |
Abadir Peter M.;Walston Jeremy D. |
分类号 |
A61K31/4178;A61K9/00 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Baltimore MD US |