| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to field of organic chemistry, namely to method of obtaining substituted quinolines of formula57-96%, where Rand R= H; R= CH, R= H; R= H, R= CH; X = H, o-CH, m-CH, p-CH, o-CH, o-Cl, m-Cl, p-Cl, p-OMe, o-OH, by interaction of anilines with 1,3-diols under action of catalysts, characterised by the fact that substituted anilines of formula XCHNH, where X is as given above, is subjected to interaction with 1,3-diols (1,3-propanediol or 1,3-butanediol) and CClin presence of catalyst, selected from the group FeCl·6HO, FeCl, FeCl·4HO, Fe(CH), Fe(acac), Fe(OAc)and Fe(CO), with molar ratio [catalyst]:[aniline]:[CCl]:[diol]=1:100:200:400, at 150°C for 8 h, obtained reaction mass is neutralized, organic layer is extracted with CHCl, filtered and solvent is distilled.EFFECT: novel method of obtaining substituted quinolines, characterised by cheapening of final product production cost due to application of available initial reagents, has been elaborated.1 tbl, 1 ex |
