发明名称 |
EFFICIENT, HIGH-YIELD CONVERSION OF MONOSACCHARIDES TO 5-(CHLOROMETHYL)-2-FURALDEHYDE |
摘要 |
The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA). |
申请公布号 |
EP2909187(A2) |
申请公布日期 |
2015.08.26 |
申请号 |
EP20130846406 |
申请日期 |
2013.09.03 |
申请人 |
XF TECHNOLOGIES INC. |
发明人 |
CAHANA, AVIAD;NIKITIN, EDWARD;STANDIFORD, JEREMY;ELLIS, KYLE;LUZHENG, ZHANG;GEORGE, TIMOTHY;MIKOCHIK, PETER |
分类号 |
C07D307/50;C07D307/46 |
主分类号 |
C07D307/50 |
代理机构 |
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代理人 |
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