ANTIBODY SPECIFICITY TRANSFER USING MINIMAL ESSENTIAL BINDING DETERMINANTS
摘要
The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.
申请公布号
EP1761561(B1)
申请公布日期
2015.08.26
申请号
EP20050711847
申请日期
2005.01.20
申请人
KALOBIOS PHARMACEUTICALS, INC.
发明人
FLYNN, PETER;LUEHRSEN, KENNETH;BALINT, ROBERT, F.;HER, JENG-HORNG;BEBBINGTON, CHRISTOPHER, R.;YARRANTON, GEOFFREY, T.