发明名称 |
REDUCING INTER-PATIENT VARIABILITY OF LEVODOPA PLASMA CONCENTRATIONS |
摘要 |
The present invention provides methods of reducing the inter-patient variability of levodopa plasma concentrations in a population of Parkinson's disease patients. The methods of the invention comprise pulmonary administration of levodopa at therapeutically effective concentrations such that the inter-patient variability of levodopa plasma concentrations at time periods ranging from about 10 minutes post inhalation to about 60 minutes or more post inhalation have less than a 50% coefficient variation. The methods of the invention are particularly useful for treatment of motor fluctuations which arise as a side effect of L-Dopa therapy. |
申请公布号 |
EP2908804(A1) |
申请公布日期 |
2015.08.26 |
申请号 |
EP20130849720 |
申请日期 |
2013.10.21 |
申请人 |
CIVITAS THERAPEUTICS, INC. |
发明人 |
BATYCKY, RICHARD, P.;FREED, MARTIN |
分类号 |
A61K9/00;A61K9/12;A61K9/14;A61K31/165;A61K31/198;A61K45/06;A61K47/02;A61K47/24 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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