发明名称 |
TDP-43-STORING CELL MODEL |
摘要 |
<p>Disclosed is a transformed cell (a cell model) which can form a cytoplasmic inclusion body derived from TAR DNA-binding protein of 43 kDa (TDP-43) that is found in the brain of a patient suffering from a neurodegenerative disease such as FTLD and ALS. The transformed cell is characterized by having, introduced therein, a promoter capable of functioning in a host cell and a mutant TDP-43 gene.</p> |
申请公布号 |
EP2272955(B1) |
申请公布日期 |
2015.08.26 |
申请号 |
EP20090730344 |
申请日期 |
2009.03.06 |
申请人 |
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE |
发明人 |
NONAKA, TAKASHI;ARAI, TETSUAKI;AKIYAMA, HARUHIKO;HASEGAWA, MASATO;YAMASHITA, MAKIKO |
分类号 |
G01N33/50;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12N15/09;C12Q1/02 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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