发明名称 |
ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY |
摘要 |
The present invention relates to ethynyl derivatives of formula I wherein Y is N or CH R1 is fluoro or chloro R2 is hydrogen or methyl or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrome, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD). |
申请公布号 |
EP2909180(A1) |
申请公布日期 |
2015.08.26 |
申请号 |
EP20130783003 |
申请日期 |
2013.10.15 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
JAESCHKE, GEORG;LINDEMANN, LOTHAR;RICCI, ANTONIO;RUEHER, DANIEL;STADLER, HEINZ;VIEIRA, ERIC |
分类号 |
C07D213/81;A61K31/4439;A61P1/00;A61P25/16;A61P25/24;C07D413/06 |
主分类号 |
C07D213/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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