| 摘要 |
A method for enhancing absorption and bioavailability of medically active or palliative ingredients comprising compounds or pharmaceutically acceptable salts thereof, the method comprising, in combination: ascertaining minimal dosage and required dissolution environments for selected medicaments; tabletting the medicament within sublingual delivery vehicles; and, creating the resultant products with enhanced bioavailability. The method applies primarily to controlled release sublingual formulations. Suitable active ingredients include pulmonary hypertension agents, vasodilators, cholesterol management tools, and agents for treating blood pressure. Several processes for producing sublingual dosage forms are outlined: in particular preparing sublingual compressed powder tablets of various shapes (e.g. round convex and round concave tablets to either slow dissolution or allow pooled saliva to improve dissolvability and reduce movement respectively), continuous eccentric sublingual capsule extrusion, offset gel strip extrusion, and sublingual waffle gel strip, dimpled gel strip and bubble gel strip preparation processes. The extruded forms preferably utilise gelatin. |
