摘要 |
The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: X is —O—, —N(R), —C(R8)(R9) or —C(O)—; and Y is —O—, —N(R), —C(R8)(R9) or —C(O)— and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ACS, secondary prevention of myocardial infarction or stroke, or PAD. |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
MANDAL, MIHIR;BLIZZARD, TIMOTHY, A.;CHEN, HELEN;CHOBANIAN, HARRY;GUO, YAN;PIO, BARBARA;WU, ZHICAI;BIFTU, TESFAYE;GREENLEE, WILLIAM, J.;ZHU, JOHNNY ZHAONING |