| 摘要 |
A composition comprising a TLR2 antagonist for use in the treatment or prophylaxis of pancreatic cancer is provided. In particular, the composition comprises a TLR2 antagonistic antibody which binds specifically to a non-continuous epitope comprising amino acid residues His318, Pro320, Arg321, Tyr323, Lys347, Phe349, Leu371, Glu375, Tyr376 and His398 of human TLR2. Also provided is a pharmaceutical composition comprising the TLR2 antagonist and the chemotherapeutic agent gemcitabine, and further provided is a screening method for the identification of compounds for use in treatment or prevention of pancreatic cancer. |
