发明名称 |
PHARMACEUTIC OSMOTIC PUMP PREPARATION |
摘要 |
Provided in the present invention is a pharmaceutic osmotic pump preparation comprising a tablet core, wherein the tablet core contains drugs (or pharmaceutically active ingredients) and materials forming a chamber structure; and a coating film coating the tablet core where a drug release hole is set; wherein when the pharmaceutic osmotic pump preparation releases drugs in water or an aqueous medium, the materials forming the chamber structure lead to the formation of a superfine chamber structure in the coating film, and the total volume of the superfine chamber structure Vb gradually increases over the releasing time, but the releasing rate R (or release amount A) of the pharmaceutically active ingredients is proportional to Vb. The osmotic pump preparation of the present invention is suitable for water-soluble drugs and water-insoluble drugs, and especially is suitable for the controlled release of low solubility drugs or pH dependent drugs. |
申请公布号 |
EP2910243(A1) |
申请公布日期 |
2015.08.26 |
申请号 |
EP20130847305 |
申请日期 |
2013.10.16 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES |
发明人 |
ZHANG, JIWEN;WU, LI;YIN, XIANZHEN;GUO, ZHEN;LI, HAIYAN |
分类号 |
A61K9/36;A61K9/22;A61K9/32;A61K31/192 |
主分类号 |
A61K9/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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