Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same

摘要

Coatings for an implantable medical device and a method of fabricating the coatings are disclosed. The coatings comprise a fluorinated polymer and a biologically beneficial polymer, an example of which includes poly(ethylene-glycol)-block poly(butylene terephthalate)-block poly(ethylene-glycol). A biologically active agent can be additionally conjugated to the biologically beneficial polymer.

主权项

1. A medical article comprising a coating disposed on at least a portion of an implantable medical device, the coating comprising:
(a) a fluorinated polymer; and (b) a biologically beneficial polymer; wherein the fluorinated polymer is selected from the group consisting of: (i) products of polymerization of fluorinated olefins; (ii) fluorine-containing cyclic polymers having a main chain with an asymmetrical cyclic structure selected from a group consisting of polymers of repeating units of cyclically polymerized perfluorallyl vinyl ether, perfluorobutenyl vinyl ether, and a combination thereof; and (iii) copolymers of perfluoro-2,2-dimethyl-1,3-dioxole with perfluoroolefins or with perfluoro(alkyl vinyl)ethers; wherein the biologically beneficial polymer is selected from the group consisting of poly(ester amide) polymers of a general formula
-[M-P]m-[M-Q]n-, and combinations of these poly(ester amide) polymers,wherein M is a moiety represented by the structure P is a moiety selected from a group (P1)-(P4) consisting of: Q is a moiety selected from a group (Q1)-(Q4) consisting of: wherein:
R1 is selected from a group consisting of a straight chained or branched aliphatic alkylene group CrH2r, wherein r is an integer having the value between 2 and 12, and an aromatic group;R2 is selected from a group consisting of hydrogen, methyl, iso-propyl, sec-butyl, iso-butyl, and benzyl;R3 is selected from a group consisting of methylene, methylmethylene, n-propylene, iso-propylene, ethylmethylene, straight chained or branched butylene, and n-amylene;X is a straight chained or branched aliphatic alkylene group CxH2x, wherein x is an integer between 2 and 12;Y is a straight chained or branched aliphatic alkylene group CyH2y, wherein y is 2, 4, or 5;Z is a biologically beneficial moiety derived from poly(ethylene glycol), poly(propylene glycol), hyaluronic acid, poly(2-hydroxyethyl methacrylate);andm and n are integers; and wherein the biologically beneficial polymer is conjugated to a biologically active agent.