| 摘要 |
The present invention provides peptides containing the amino acid sequence of SEQ ID NOs: 1, 2, 3, 4, 16, 17, 30, 31, 34, 36, 37, 40, 41, 45, 49, 55, 57 and 61, as well as peptides containing the above-mentioned amino acid sequences in which 1, 2, or several amino acid(s) are substituted, deleted, inserted or added, but still have cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing tumors, which drugs containing these peptides. The peptides of the present invention can also be used as vaccines. |
| 主权项 |
1. A method of inducing an immune response against hepatocellular carcinoma in a subject, said hepatocellular carcinoma expressing WD repeat protein upregulated in hepatocellular carcinoma (WDRPUH) comprising the amino acid sequence set forth in SEQ ID NO: 64, said method comprising the step of administering to the subject an agent comprising an isolated peptide of less than 15 amino acids selected from the group consisting of:
(a) an isolated peptide, which comprises the amino acid sequence as shown in SEQ ID NO: 34; and (b) an isolated peptide, which comprises the amino acid sequence as shown in SEQ ID NO: 34 in which 1 or 2 amino acid(s) are substituted and/or added, wherein the added amino acid(s) are added to the N-terminus and/or the C-terminus. |
